<?xml version="1.0" encoding="UTF-8"?>
<PharmML 
	xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" 
	xmlns="http://www.pharmml.org/pharmml/0.8/PharmML"
	xsi:schemaLocation="http://www.pharmml.org/pharmml/0.8/PharmML http://www.pharmml.org/pharmml/0.8/PharmML"
	xmlns:math="http://www.pharmml.org/pharmml/0.8/Maths"
	xmlns:ct="http://www.pharmml.org/pharmml/0.8/CommonTypes"
	xmlns:ds="http://www.pharmml.org/pharmml/0.8/Dataset"
	xmlns:mdef="http://www.pharmml.org/pharmml/0.8/ModelDefinition"
	xmlns:mstep="http://www.pharmml.org/pharmml/0.8/ModellingSteps"
	xmlns:design="http://www.pharmml.org/pharmml/0.8/TrialDesign"
	writtenVersion="0.8.1">
	<ct:Name>Generated from MDL. MOG ID: warfarin_PK_ODE_mog</ct:Name>
	<IndependentVariable symbId="T"/>
	<!-- SQRT(PROP**2 + (ADD/F)**2) -->
	<ct:FunctionDefinition xmlns="http://www.pharmml.org/pharmml/0.8/CommonTypes" 
		symbolType="real"
		symbId="combinedError2Log">
	    <ct:Description>Combined additive ad proportional for 1 epsilon where prediction is log transformed</ct:Description>
	    <ct:FunctionArgument symbolType="real" symbId="additive"/>
	    <ct:FunctionArgument symbolType="real" symbId="proportional"/>
	    <ct:FunctionArgument symbolType="real" symbId="f"/>
	    <ct:Definition>
	        <Assign>
	            <Uniop op="sqrt" xmlns="http://www.pharmml.org/pharmml/0.8/Maths">
	                <Binop op="plus">
	                    <Binop op="times">
	                        <ct:SymbRef symbIdRef="proportional"/>
	                        <ct:SymbRef symbIdRef="proportional"/>
	                    </Binop>
	                    <Binop op="power">
	                        <Binop op="divide">
	                            <ct:SymbRef symbIdRef="additive"/>
	                            <ct:SymbRef symbIdRef="f"/>
	                        </Binop>
	                        <ct:Int>2</ct:Int>
	                    </Binop>
	                </Binop>
	            </Uniop>
	        </Assign>
	    </ct:Definition>
	</ct:FunctionDefinition>
	<ModelDefinition xmlns="http://www.pharmml.org/pharmml/0.8/ModelDefinition">
		<VariabilityModel blkId="vm_err" type="residualError">
			<Level symbId="DV"/>
		</VariabilityModel>
		<VariabilityModel blkId="vm_mdl" type="parameterVariability">
			<Level symbId="MDL__prior"/>
			<Level symbId="ID">
				<ParentLevel>
					<ct:SymbRef symbIdRef="MDL__prior"/>
				</ParentLevel>
			</Level>
		</VariabilityModel>
		<CovariateModel blkId="cm">
			<Covariate symbId="CL">
				<Continuous/>
			</Covariate>
		</CovariateModel>
		<ParameterModel blkId="pm">
			<PopulationParameter symbId="MU_CL">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.1</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_V">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Int>8</ct:Int>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_KA">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.362</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_TLAG">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Int>1</ct:Int>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_PPV_CL">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.1</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_PPV_V">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.1</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_PPV_KA">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.1</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_CORR_CL_V">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.01</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_RUV_PROP">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.1</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_RUV_ADD">
				<ct:Assign>
					<math:Uniop op="log">
						<ct:Real>0.1</ct:Real>
					</math:Uniop>	
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_CL">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_V">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_KA">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_TLAG">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_PPV_CL">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_PPV_V">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_PPV_KA">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_CORR_CL_V">
				<ct:Assign>
					<ct:Int>2</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_RUV_PROP">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_RUV_ADD">
				<ct:Assign>
					<ct:Real>1.5</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_IMAX">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_IC50">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_BM0">
				<ct:Assign>
					<ct:Real>59.7</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_MRT">
				<ct:Assign>
					<ct:Int>91</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_HILL">
				<ct:Assign>
					<ct:Real>3.31</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_TVSLP">
				<ct:Assign>
					<ct:Real>0.035</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_BM02">
				<ct:Assign>
					<ct:Int>8670</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_MRT2">
				<ct:Assign>
					<ct:Int>554</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_HILL2">
				<ct:Assign>
					<ct:Real>1.54</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_BM03">
				<ct:Assign>
					<ct:Int>63900</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_MRT3">
				<ct:Assign>
					<ct:Int>401</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_BM0S">
				<ct:Assign>
					<ct:Int>39200</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_MRTS">
				<ct:Assign>
					<ct:Int>2430</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_RES_VEGF_PROP">
				<ct:Assign>
					<ct:Real>0.445</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_RES_sVEGFR2_PROP">
				<ct:Assign>
					<ct:Real>0.12</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_RES_sVEGFR2_ADD">
				<ct:Assign>
					<ct:Int>583</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_RES_sVEGFR3_PROP">
				<ct:Assign>
					<ct:Real>0.22</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="POP_RES_sKIT_PROP">
				<ct:Assign>
					<ct:Real>0.224</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_BM0">
				<ct:Assign>
					<ct:Real>0.252</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_BM02">
				<ct:Assign>
					<ct:Real>0.0369</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_BM03">
				<ct:Assign>
					<ct:Real>0.186</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_BM0S">
				<ct:Assign>
					<ct:Real>0.254</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_MRT_VEGFs">
				<ct:Assign>
					<ct:Real>0.06</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_MRT_sKIT">
				<ct:Assign>
					<ct:Real>0.0753</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_IC50">
				<ct:Assign>
					<ct:Real>0.253</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_IC502">
				<ct:Assign>
					<ct:Real>0.189</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_IC503">
				<ct:Assign>
					<ct:Real>0.398</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_IC50S">
				<ct:Assign>
					<ct:Real>5.77</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_TVSLP">
				<ct:Assign>
					<ct:Real>2.95</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="OMEGA_TVSLPS">
				<ct:Assign>
					<ct:Real>3.01</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="SIGMA_RES_W">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<RandomVariable symbId="eta_BM0">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_BM0"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_BM02">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_BM02"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_BM03">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_BM03"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_BM0S">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_BM0S"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_MRT_VEGFs">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_MRT_VEGFs"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_MRT_sKIT">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_MRT_sKIT"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_IC50">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_IC50"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_IC502">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_IC502"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_IC503">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_IC503"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_IC50S">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_IC50S"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_TVSLP">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_TVSLP"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="eta_TVSLPS">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="OMEGA_TVSLPS"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<IndividualParameter symbId="BM0">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_BM0"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_BM0"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="BM02">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_BM02"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_BM02"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="BM03">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_BM03"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_BM03"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="BM0S">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_BM0S"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_BM0S"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="IMAX1">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IMAX"/>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="IMAX2">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IMAX"/>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="IMAX3">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IMAX"/>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="IMAXS">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IMAX"/>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="IC50">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IC50"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_IC50"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="IC502">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IC50"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_IC502"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="IC503">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IC50"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_IC503"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="IC50S">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_IC50"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_IC50S"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="HILL">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="POP_HILL"/>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="HILL2">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="POP_HILL2"/>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="MRT1">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_MRT"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_MRT_VEGFs"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="MRT2">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_MRT2"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_MRT_VEGFs"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="MRT3">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_MRT3"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_MRT_VEGFs"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="MRTS">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="POP_MRTS"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_MRT_sKIT"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="TVSLP">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:SymbRef blkIdRef="pm" symbIdRef="POP_TVSLP"/>
						<ct:Int>1000</ct:Int>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="DPSLP">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="TVSLP"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_TVSLP"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="TVSLPS">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:SymbRef blkIdRef="pm" symbIdRef="POP_TVSLP"/>
						<ct:Int>1000</ct:Int>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="DPSLPS">
				<StructuredModel>
					<Transformation type="log" />
					<LinearCovariate>
						<PopulationValue>
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="TVSLPS"/>
							</ct:Assign>
						</PopulationValue>
					</LinearCovariate>
					<RandomEffects>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eta_TVSLPS"/>
					</RandomEffects>
				</StructuredModel>
			</IndividualParameter>
			<IndividualParameter symbId="KOUT">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:Int>1</ct:Int>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MRT1"/>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="KOUT2">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:Int>1</ct:Int>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MRT2"/>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="KOUT3">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:Int>1</ct:Int>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MRT3"/>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="KOUTS">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:Int>1</ct:Int>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MRTS"/>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="KIN2">
				<ct:Assign>
					<math:Binop op="times">
						<ct:SymbRef blkIdRef="pm" symbIdRef="BM02"/>
						<ct:SymbRef blkIdRef="pm" symbIdRef="KOUT2"/>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="KIN3">
				<ct:Assign>
					<math:Binop op="times">
						<ct:SymbRef blkIdRef="pm" symbIdRef="BM03"/>
						<ct:SymbRef blkIdRef="pm" symbIdRef="KOUT3"/>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<RandomVariable symbId="eps_RES_W">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_err" symbIdRef="DV"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="SIGMA_RES_W"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
		</ParameterModel>
		<StructuralModel blkId="sm">
			<ct:Variable symbId="DOSE" symbolType="real">
			</ct:Variable>
			<ct:Variable symbId="AUC" symbolType="real">
				<ct:Assign>
					<math:Binop op="divide">
						<ct:SymbRef blkIdRef="sm" symbIdRef="DOSE"/>
						<ct:SymbRef blkIdRef="cm" symbIdRef="CL"/>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="DP1" symbolType="real">
				<ct:Assign>
					<math:Binop op="times">
						<ct:SymbRef blkIdRef="pm" symbIdRef="BM0"/>
						<math:Binop op="plus">
							<ct:Int>1</ct:Int>
							<math:Binop op="times">
								<ct:SymbRef blkIdRef="pm" symbIdRef="DPSLP"/>
								<ct:SymbRef symbIdRef="T"/>
							</math:Binop>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="DPS" symbolType="real">
				<ct:Assign>
					<math:Binop op="times">
						<ct:SymbRef blkIdRef="pm" symbIdRef="BM0S"/>
						<math:Binop op="plus">
							<ct:Int>1</ct:Int>
							<math:Binop op="times">
								<ct:SymbRef blkIdRef="pm" symbIdRef="DPSLPS"/>
								<ct:SymbRef symbIdRef="T"/>
							</math:Binop>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="KIN" symbolType="real">
				<ct:Assign>
					<math:Binop op="times">
						<ct:SymbRef blkIdRef="sm" symbIdRef="DP1"/>
						<ct:SymbRef blkIdRef="pm" symbIdRef="KOUT"/>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="KINS" symbolType="real">
				<ct:Assign>
					<math:Binop op="times">
						<ct:SymbRef blkIdRef="sm" symbIdRef="DPS"/>
						<ct:SymbRef blkIdRef="pm" symbIdRef="KOUTS"/>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="EFF" symbolType="real">
				<ct:Assign>
					<math:Binop op="divide">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="IMAX1"/>
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
								<ct:SymbRef blkIdRef="pm" symbIdRef="HILL"/>
							</math:Binop>
						</math:Binop>
						<math:Binop op="plus">
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="pm" symbIdRef="IC50"/>
								<ct:SymbRef blkIdRef="pm" symbIdRef="HILL"/>
							</math:Binop>
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
								<ct:SymbRef blkIdRef="pm" symbIdRef="HILL"/>
							</math:Binop>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="EFF2" symbolType="real">
				<ct:Assign>
					<math:Binop op="divide">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="IMAX2"/>
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
								<ct:SymbRef blkIdRef="pm" symbIdRef="HILL2"/>
							</math:Binop>
						</math:Binop>
						<math:Binop op="plus">
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="pm" symbIdRef="IC502"/>
								<ct:SymbRef blkIdRef="pm" symbIdRef="HILL2"/>
							</math:Binop>
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
								<ct:SymbRef blkIdRef="pm" symbIdRef="HILL2"/>
							</math:Binop>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="EFF3" symbolType="real">
				<ct:Assign>
					<math:Binop op="divide">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="IMAX3"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
						</math:Binop>
						<math:Binop op="plus">
							<ct:SymbRef blkIdRef="pm" symbIdRef="IC503"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="EFFS" symbolType="real">
				<ct:Assign>
					<math:Binop op="divide">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="IMAXS"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
						</math:Binop>
						<math:Binop op="plus">
							<ct:SymbRef blkIdRef="pm" symbIdRef="IC50S"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="AUC"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</ct:Variable>
			<ct:DerivativeVariable symbId="VEGF" symbolType="real">
				<ct:Assign>
					<math:Binop op="minus">
						<ct:SymbRef blkIdRef="sm" symbIdRef="KIN"/>
						<math:Binop op="times">
							<math:Binop op="times">
								<ct:SymbRef blkIdRef="pm" symbIdRef="KOUT"/>
								<math:Binop op="minus">
									<ct:Int>1</ct:Int>
									<ct:SymbRef blkIdRef="sm" symbIdRef="EFF"/>
								</math:Binop>
							</math:Binop>
							<ct:SymbRef blkIdRef="sm" symbIdRef="VEGF"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
				<ct:IndependentVariable>
					<ct:SymbRef symbIdRef="T"/>
				</ct:IndependentVariable>
				<ct:InitialCondition>
					<ct:InitialValue>
						<ct:Assign>
							<ct:SymbRef blkIdRef="pm" symbIdRef="BM0"/>
						</ct:Assign>
					</ct:InitialValue>
					<ct:InitialTime>
						<ct:Assign>
							<ct:Int>0</ct:Int>
						</ct:Assign>	
					</ct:InitialTime>
				</ct:InitialCondition>
			</ct:DerivativeVariable>
			<ct:DerivativeVariable symbId="sVEGFR2" symbolType="real">
				<ct:Assign>
					<math:Binop op="minus">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="KIN2"/>
							<math:Binop op="minus">
								<ct:Int>1</ct:Int>
								<ct:SymbRef blkIdRef="sm" symbIdRef="EFF2"/>
							</math:Binop>
						</math:Binop>
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="KOUT2"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="sVEGFR2"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
				<ct:IndependentVariable>
					<ct:SymbRef symbIdRef="T"/>
				</ct:IndependentVariable>
				<ct:InitialCondition>
					<ct:InitialValue>
						<ct:Assign>
							<ct:SymbRef blkIdRef="pm" symbIdRef="BM02"/>
						</ct:Assign>
					</ct:InitialValue>
					<ct:InitialTime>
						<ct:Assign>
							<ct:Int>0</ct:Int>
						</ct:Assign>	
					</ct:InitialTime>
				</ct:InitialCondition>
			</ct:DerivativeVariable>
			<ct:DerivativeVariable symbId="sVEGFR3" symbolType="real">
				<ct:Assign>
					<math:Binop op="minus">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="KIN3"/>
							<math:Binop op="minus">
								<ct:Int>1</ct:Int>
								<ct:SymbRef blkIdRef="sm" symbIdRef="EFF3"/>
							</math:Binop>
						</math:Binop>
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="KOUT3"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="sVEGFR3"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
				<ct:IndependentVariable>
					<ct:SymbRef symbIdRef="T"/>
				</ct:IndependentVariable>
				<ct:InitialCondition>
					<ct:InitialValue>
						<ct:Assign>
							<ct:SymbRef blkIdRef="pm" symbIdRef="BM03"/>
						</ct:Assign>
					</ct:InitialValue>
					<ct:InitialTime>
						<ct:Assign>
							<ct:Int>0</ct:Int>
						</ct:Assign>	
					</ct:InitialTime>
				</ct:InitialCondition>
			</ct:DerivativeVariable>
			<ct:DerivativeVariable symbId="sKIT" symbolType="real">
				<ct:Assign>
					<math:Binop op="minus">
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="sm" symbIdRef="KINS"/>
							<math:Binop op="minus">
								<ct:Int>1</ct:Int>
								<ct:SymbRef blkIdRef="sm" symbIdRef="EFFS"/>
							</math:Binop>
						</math:Binop>
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="KOUTS"/>
							<ct:SymbRef blkIdRef="sm" symbIdRef="sKIT"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
				<ct:IndependentVariable>
					<ct:SymbRef symbIdRef="T"/>
				</ct:IndependentVariable>
				<ct:InitialCondition>
					<ct:InitialValue>
						<ct:Assign>
							<ct:SymbRef blkIdRef="pm" symbIdRef="BM0S"/>
						</ct:Assign>
					</ct:InitialValue>
					<ct:InitialTime>
						<ct:Assign>
							<ct:Int>0</ct:Int>
						</ct:Assign>	
					</ct:InitialTime>
				</ct:InitialCondition>
			</ct:DerivativeVariable>
		</StructuralModel>
		<ObservationModel blkId="om1">
			<ContinuousData>
				<Standard symbId="LNVEGF_obs">
					<Transformation type="log"/>
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="VEGF"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="combinedError2Log"/>
								<math:FunctionArgument symbId="additive">
									<ct:Int>0</ct:Int>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="proportional">
									<ct:SymbRef blkIdRef="pm" symbIdRef="POP_RES_VEGF_PROP"/>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="f">
									<ct:SymbRef blkIdRef="sm" symbIdRef="VEGF"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eps_RES_W"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
		<ObservationModel blkId="om2">
			<ContinuousData>
				<Standard symbId="LNsVEGFR2_obs">
					<Transformation type="log"/>
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="sVEGFR2"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="combinedError2Log"/>
								<math:FunctionArgument symbId="additive">
									<ct:SymbRef blkIdRef="pm" symbIdRef="POP_RES_sVEGFR2_ADD"/>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="proportional">
									<ct:SymbRef blkIdRef="pm" symbIdRef="POP_RES_sVEGFR2_PROP"/>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="f">
									<ct:SymbRef blkIdRef="sm" symbIdRef="sVEGFR2"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eps_RES_W"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
		<ObservationModel blkId="om3">
			<ContinuousData>
				<Standard symbId="LNsVEGFR3_obs">
					<Transformation type="log"/>
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="sVEGFR3"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="combinedError2Log"/>
								<math:FunctionArgument symbId="additive">
									<ct:Int>0</ct:Int>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="proportional">
									<ct:SymbRef blkIdRef="pm" symbIdRef="POP_RES_sVEGFR3_PROP"/>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="f">
									<ct:SymbRef blkIdRef="sm" symbIdRef="sVEGFR3"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eps_RES_W"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
		<ObservationModel blkId="om4">
			<ContinuousData>
				<Standard symbId="LNsKIT_obs">
					<Transformation type="log"/>
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="sKIT"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="combinedError2Log"/>
								<math:FunctionArgument symbId="additive">
									<ct:Int>0</ct:Int>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="proportional">
									<ct:SymbRef blkIdRef="pm" symbIdRef="POP_RES_sKIT_PROP"/>
								</math:FunctionArgument>
								<math:FunctionArgument symbId="f">
									<ct:SymbRef blkIdRef="sm" symbIdRef="sKIT"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="eps_RES_W"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
	</ModelDefinition>
	<TrialDesign xmlns="http://www.pharmml.org/pharmml/0.8/TrialDesign">
		<ExternalDataSet toolName="NONMEM" oid="nm_ds">
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="ID"/>
				<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="TIME"/>
				<ct:SymbRef symbIdRef="T"/>
			</ColumnMapping>
			<MultipleDVMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="DV"/>
				<Piecewise>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om1" symbIdRef="LNVEGF_obs"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="FLAG"/>
								<ct:Int>5</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om2" symbIdRef="LNsVEGFR2_obs"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="FLAG"/>
								<ct:Int>6</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om3" symbIdRef="LNsVEGFR3_obs"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="FLAG"/>
								<ct:Int>7</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om4" symbIdRef="LNsKIT_obs"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="FLAG"/>
								<ct:Int>8</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
				</Piecewise>
			</MultipleDVMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="AMT"/>
				<math:Piecewise>
					<math:Piece>
						<ct:SymbRef blkIdRef="sm" symbIdRef="DOSE"/>
						<math:Condition>
							<math:LogicBinop op="gt">
								<ds:ColumnRef columnIdRef="AMT"/>
								<ct:Int>0</ct:Int>
							</math:LogicBinop>
						</math:Condition>
					</math:Piece>
				</math:Piecewise>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="CL"/>
				<ct:SymbRef blkIdRef="cm" symbIdRef="CL"/>
			</ColumnMapping>
			<DataSet xmlns="http://www.pharmml.org/pharmml/0.8/Dataset">
				<Definition>
					<Column columnId="ID" columnType="id" valueType="int" columnNum="1"/>
					<Column columnId="CYCL" columnType="undefined" valueType="real" columnNum="2"/>
					<Column columnId="TIME" columnType="idv" valueType="real" columnNum="3"/>
					<Column columnId="FLAG" columnType="dvid" valueType="int" columnNum="4"/>
					<Column columnId="DVX" columnType="undefined" valueType="real" columnNum="5"/>
					<Column columnId="DV" columnType="dv" valueType="real" columnNum="6"/>
					<Column columnId="AMT" columnType="dose" valueType="real" columnNum="7"/>
					<Column columnId="PLA" columnType="undefined" valueType="real" columnNum="8"/>
					<Column columnId="CL" columnType="covariate" valueType="real" columnNum="9"/>
					<Column columnId="EVID" columnType="undefined" valueType="real" columnNum="10"/>
				</Definition>
				<ExternalFile oid="id">
					<path>BIOMARKER_simDATA.csv</path>
					<format>CSV</format>
					<delimiter>COMMA</delimiter>
				</ExternalFile>
			</DataSet>
		</ExternalDataSet>
	</TrialDesign>
	<ModellingSteps xmlns="http://www.pharmml.org/pharmml/0.8/ModellingSteps">
		<EstimationStep oid="estimStep_1">
			<ExternalDataSetReference>
				<ct:OidRef oidRef="nm_ds"/>
			</ExternalDataSetReference>
			<ParametersToEstimate>
			</ParametersToEstimate>
			<Operation order="1" opType="generic">
				<Property name="algo">
					<ct:Assign>
						<ct:String>mcmc</ct:String>
					</ct:Assign>
				</Property>
			</Operation>
			<Operation order="2" opType="BUGS">
				<Property name="nchains">
					<ct:Assign>
						<ct:Int>1</ct:Int>
					</ct:Assign>
				</Property>
				<Property name="burnin">
					<ct:Assign>
						<ct:Int>1</ct:Int>
					</ct:Assign>
				</Property>
				<Property name="niter">
					<ct:Assign>
						<ct:Int>1</ct:Int>
					</ct:Assign>
				</Property>
				<Property name="winbugsgui">
					<ct:Assign>
						<ct:String>true</ct:String>
					</ct:Assign>
				</Property>
			</Operation>
		</EstimationStep>
		<mstep:StepDependencies>
			<mstep:Step>
				<ct:OidRef oidRef="estimStep_1"/>
			</mstep:Step>
		</mstep:StepDependencies>
	</ModellingSteps>		
</PharmML>
