<?xml version="1.0" encoding="UTF-8"?>
<PharmML 
	xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" 
	xmlns="http://www.pharmml.org/pharmml/0.8/PharmML"
	xsi:schemaLocation="http://www.pharmml.org/pharmml/0.8/PharmML http://www.pharmml.org/pharmml/0.8/PharmML"
	xmlns:math="http://www.pharmml.org/pharmml/0.8/Maths"
	xmlns:ct="http://www.pharmml.org/pharmml/0.8/CommonTypes"
	xmlns:ds="http://www.pharmml.org/pharmml/0.8/Dataset"
	xmlns:mdef="http://www.pharmml.org/pharmml/0.8/ModelDefinition"
	xmlns:mstep="http://www.pharmml.org/pharmml/0.8/ModellingSteps"
	xmlns:design="http://www.pharmml.org/pharmml/0.8/TrialDesign"
	writtenVersion="0.8.1">
	<ct:Name>Generated from MDL. MOG ID: magni2000_mog</ct:Name>
	<IndependentVariable symbId="T"/>
	<ct:FunctionDefinition xmlns="http://www.pharmml.org/pharmml/0.8/CommonTypes"
		symbolType="real"
		symbId="additiveError">
	    <ct:Description>Constant or additive error model</ct:Description>
	    <ct:FunctionArgument symbolType="real" symbId="additive"/>
	    <ct:Definition>
	        <Assign>
	           <ct:SymbRef symbIdRef="additive"/>
	        </Assign>
	    </ct:Definition>
	</ct:FunctionDefinition>
	<ModelDefinition xmlns="http://www.pharmml.org/pharmml/0.8/ModelDefinition">
		<VariabilityModel blkId="vm_err" type="residualError">
			<Level symbId="DV"/>
		</VariabilityModel>
		<VariabilityModel blkId="vm_mdl" type="parameterVariability">
			<Level symbId="MDL__prior"/>
			<Level symbId="ID">
				<ParentLevel>
					<ct:SymbRef symbIdRef="MDL__prior"/>
				</ParentLevel>
			</Level>
		</VariabilityModel>
		<CovariateModel blkId="cm">
			<Covariate symbId="HSTATUS">
				<Continuous/>
			</Covariate>
			<Covariate symbId="FEMALE">
				<Continuous/>
			</Covariate>
			<Covariate symbId="AGE">
				<Continuous/>
			</Covariate>
			<Covariate symbId="WEIGHT">
				<Continuous/>
			</Covariate>
			<Covariate symbId="HEIGHT">
				<Continuous/>
			</Covariate>
		</CovariateModel>
		<ParameterModel blkId="pm">
			<PopulationParameter symbId="MU_mtsn">
				<ct:Assign>
					<ct:Int>5</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_mtso">
				<ct:Assign>
					<ct:Int>5</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_mtsd">
				<ct:Assign>
					<ct:Int>5</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_mFn">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_mFo">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_mFd">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_atl">
				<ct:Assign>
					<ct:Int>30</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_btl">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_aVm">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_bVm">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_aVf">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MU_bVf">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_mtsn">
				<ct:Assign>
					<math:Binop op="power">
						<ct:Int>5</ct:Int>
						<ct:Int>2</ct:Int>
					</math:Binop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_mtso">
				<ct:Assign>
					<math:Binop op="power">
						<ct:Int>5</ct:Int>
						<ct:Int>2</ct:Int>
					</math:Binop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_mtsd">
				<ct:Assign>
					<math:Binop op="power">
						<ct:Int>5</ct:Int>
						<ct:Int>2</ct:Int>
					</math:Binop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_mFn">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_mFo">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_mFd">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_atl">
				<ct:Assign>
					<math:Binop op="power">
						<ct:Int>30</ct:Int>
						<ct:Int>2</ct:Int>
					</math:Binop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_btl">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_aVm">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_bVm">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_aVf">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="VAR_bVf">
				<ct:Assign>
					<ct:Int>1</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="R">
				<ct:Assign>
					<math:MatrixUniop op="inverse">
						<ct:Matrix matrixType="Any">
							<ct:MatrixRow>
								<ct:Assign>
									<ct:Real>0.5</ct:Real>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
							</ct:MatrixRow>
							<ct:MatrixRow>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Real>0.1</ct:Real>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
							</ct:MatrixRow>
							<ct:MatrixRow>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
							</ct:MatrixRow>
							<ct:MatrixRow>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Int>0</ct:Int>
								</ct:Assign>
								<ct:Assign>
									<ct:Real>0.4</ct:Real>
								</ct:Assign>
							</ct:MatrixRow>
						</ct:Matrix>
					</math:MatrixUniop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="rho">
				<ct:Assign>
					<ct:Int>10</ct:Int>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="mtsn">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_mtsn"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_mtsn"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="mtso">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_mtso"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_mtso"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="mtsd">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_mtsd"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_mtsd"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="mFn">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_mFn"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_mFn"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="mFo">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_mFo"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_mFo"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="mFd">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_mFd"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_mFd"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="atl">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_atl"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_atl"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="btl">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_btl"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_btl"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="aVm">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_aVm"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_aVm"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="bVm">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_bVm"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_bVm"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="aVf">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_aVf"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_aVf"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="bVf">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MU_bVf"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="VAR_bVf"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="invOMEGA_PAR">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="MDL__prior"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Wishart1">
						<Parameter name="scaleMatrix">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="R"/>
							</ct:Assign>
						</Parameter>
						<Parameter name="degreesOfFreedom">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="rho"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</PopulationParameter>
			<PopulationParameter symbId="MATRIX_1">
				<ct:Assign>
					<math:MatrixUniop op="inverse">
						<ct:SymbRef blkIdRef="pm" symbIdRef="invOMEGA_PAR"/>
					</math:MatrixUniop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="SIGMA2_ts">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>1</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>1</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="SIGMA2_F">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>2</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>2</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="SIGMA2_tl">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="SIGMA2_V">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>4</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>4</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="COV_ts_F">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>2</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>1</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="COV_ts_tl">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>1</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="COV_F_tl">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>2</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="COV_ts_V">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>4</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>1</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="COV_F_V">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>4</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>2</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="COV_tl_V">
				<ct:Assign>
					<ct:MatrixSelector>
						<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1"/>
						<ct:Cell>
							<ct:RowIndex>
								<ct:Assign>
									<ct:Int>4</ct:Int>
								</ct:Assign>
							</ct:RowIndex>
							<ct:ColumnIndex>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
							</ct:ColumnIndex>
						</ct:Cell>
					</ct:MatrixSelector>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="ADD_SMALL">
				<ct:Assign>
					<ct:Real>1.0E-20</ct:Real>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="MATRIX_1_mdl">
				<ct:Assign>
					<ct:Matrix matrixType="LowerTriangular">
						<ct:MatrixRow>
							<ct:SymbRef blkIdRef="pm" symbIdRef="SIGMA2_ts"/>
						</ct:MatrixRow>
						<ct:MatrixRow>
							<ct:SymbRef blkIdRef="pm" symbIdRef="COV_ts_F"/>
							<ct:SymbRef blkIdRef="pm" symbIdRef="SIGMA2_F"/>
						</ct:MatrixRow>
						<ct:MatrixRow>
							<ct:SymbRef blkIdRef="pm" symbIdRef="COV_ts_tl"/>
							<ct:SymbRef blkIdRef="pm" symbIdRef="COV_F_tl"/>
							<ct:SymbRef blkIdRef="pm" symbIdRef="SIGMA2_tl"/>
						</ct:MatrixRow>
						<ct:MatrixRow>
							<ct:SymbRef blkIdRef="pm" symbIdRef="COV_ts_V"/>
							<ct:SymbRef blkIdRef="pm" symbIdRef="COV_F_V"/>
							<ct:SymbRef blkIdRef="pm" symbIdRef="COV_tl_V"/>
							<ct:SymbRef blkIdRef="pm" symbIdRef="SIGMA2_V"/>
						</ct:MatrixRow>
					</ct:Matrix>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="BSA">
				<ct:Assign>
					<math:Binop op="times">
						<math:Binop op="times">
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="cm" symbIdRef="WEIGHT"/>
								<ct:Real>0.425</ct:Real>
							</math:Binop>
							<math:Binop op="power">
								<ct:SymbRef blkIdRef="cm" symbIdRef="HEIGHT"/>
								<ct:Real>0.725</ct:Real>
							</math:Binop>
						</math:Binop>
						<ct:Real>0.007184</ct:Real>
					</math:Binop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="GROUP_tl">
				<ct:Assign>
					<math:Binop op="plus">
						<ct:SymbRef blkIdRef="pm" symbIdRef="atl"/>
						<math:Binop op="times">
							<ct:SymbRef blkIdRef="pm" symbIdRef="btl"/>
							<ct:SymbRef blkIdRef="cm" symbIdRef="AGE"/>
						</math:Binop>
					</math:Binop>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="GROUP_ts">
				<ct:Assign>
					<math:Piecewise>
						<math:Piece>
							<ct:SymbRef blkIdRef="pm" symbIdRef="mtsn"/>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
									<ct:Int>1</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
						<math:Piece>
							<ct:SymbRef blkIdRef="pm" symbIdRef="mtso"/>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
									<ct:Int>2</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
						<math:Piece>
							<ct:SymbRef blkIdRef="pm" symbIdRef="mtsd"/>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
									<ct:Int>3</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
					</math:Piecewise>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="GROUP_F">
				<ct:Assign>
					<math:Piecewise>
						<math:Piece>
							<ct:SymbRef blkIdRef="pm" symbIdRef="mFn"/>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
									<ct:Int>1</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
						<math:Piece>
							<ct:SymbRef blkIdRef="pm" symbIdRef="mFo"/>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
									<ct:Int>2</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
						<math:Piece>
							<ct:SymbRef blkIdRef="pm" symbIdRef="mFd"/>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
									<ct:Int>3</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
					</math:Piecewise>
				</ct:Assign>
			</PopulationParameter>
			<PopulationParameter symbId="GROUP_V">
				<ct:Assign>
					<math:Piecewise>
						<math:Piece>
							<math:Binop op="plus">
								<ct:SymbRef blkIdRef="pm" symbIdRef="aVm"/>
								<math:Binop op="times">
									<ct:SymbRef blkIdRef="pm" symbIdRef="bVm"/>
									<ct:SymbRef blkIdRef="pm" symbIdRef="BSA"/>
								</math:Binop>
							</math:Binop>
							<math:Condition>
								<math:LogicBinop op="eq">
									<ct:SymbRef blkIdRef="cm" symbIdRef="FEMALE"/>
									<ct:Int>0</ct:Int>
								</math:LogicBinop>
							</math:Condition>
						</math:Piece>
						<math:Piece>
							<math:Binop op="plus">
								<ct:SymbRef blkIdRef="pm" symbIdRef="aVf"/>
								<math:Binop op="times">
									<ct:SymbRef blkIdRef="pm" symbIdRef="bVf"/>
									<ct:SymbRef blkIdRef="pm" symbIdRef="BSA"/>
								</math:Binop>
							</math:Binop>
							<math:Condition>
								<math:Otherwise/>
							</math:Condition>
						</math:Piece>
					</math:Piecewise>
				</ct:Assign>
			</PopulationParameter>
			<IndividualParameter symbId="ts_IND">
				<ct:Assign>
					<math:Binop op="plus">
						<ct:SymbRef blkIdRef="pm" symbIdRef="GROUP_ts"/>
						<ct:VectorSelector>
							<ct:SymbRef blkIdRef="pm" symbIdRef="eta_4"/>
							<ct:Cell>
								<ct:Assign>
									<ct:Int>1</ct:Int>
								</ct:Assign>
							</ct:Cell>
						</ct:VectorSelector>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="F_IND">
				<ct:Assign>
					<math:Binop op="plus">
						<ct:SymbRef blkIdRef="pm" symbIdRef="GROUP_F"/>
						<ct:VectorSelector>
							<ct:SymbRef blkIdRef="pm" symbIdRef="eta_4"/>
							<ct:Cell>
								<ct:Assign>
									<ct:Int>2</ct:Int>
								</ct:Assign>
							</ct:Cell>
						</ct:VectorSelector>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="tl_IND">
				<ct:Assign>
					<math:Binop op="plus">
						<ct:SymbRef blkIdRef="pm" symbIdRef="GROUP_tl"/>
						<ct:VectorSelector>
							<ct:SymbRef blkIdRef="pm" symbIdRef="eta_4"/>
							<ct:Cell>
								<ct:Assign>
									<ct:Int>3</ct:Int>
								</ct:Assign>
							</ct:Cell>
						</ct:VectorSelector>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<IndividualParameter symbId="V_IND">
				<ct:Assign>
					<math:Binop op="plus">
						<ct:SymbRef blkIdRef="pm" symbIdRef="GROUP_V"/>
						<ct:VectorSelector>
							<ct:SymbRef blkIdRef="pm" symbIdRef="eta_4"/>
							<ct:Cell>
								<ct:Assign>
									<ct:Int>4</ct:Int>
								</ct:Assign>
							</ct:Cell>
						</ct:VectorSelector>
					</math:Binop>
				</ct:Assign>
			</IndividualParameter>
			<RandomVariable symbId="eta_4">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="MultivariateNormal1">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Vector>
									<ct:VectorElements>
										<ct:Int>0</ct:Int>
										<ct:Int>0</ct:Int>
										<ct:Int>0</ct:Int>
										<ct:Int>0</ct:Int>
									</ct:VectorElements>
								</ct:Vector>
							</ct:Assign>
						</Parameter>
						<Parameter name="covarianceMatrix">
							<ct:Assign>
								<ct:SymbRef blkIdRef="pm" symbIdRef="MATRIX_1_mdl"/>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
			<RandomVariable symbId="EPS">
				<ct:VariabilityReference>
					<ct:SymbRef blkIdRef="vm_err" symbIdRef="DV"/>
				</ct:VariabilityReference>
				<Distribution>
					<ProbOnto xmlns="http://www.pharmml.org/probonto/ProbOnto" name="Normal2">
						<Parameter name="mean">
							<ct:Assign>
								<ct:Int>0</ct:Int>
							</ct:Assign>
						</Parameter>
						<Parameter name="var">
							<ct:Assign>
								<ct:Int>1</ct:Int>
							</ct:Assign>
						</Parameter>
					</ProbOnto>
				</Distribution>
			</RandomVariable>
		</ParameterModel>
		<StructuralModel blkId="sm">
			<ct:Variable symbId="ts_PRED" symbolType="real">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="ts_IND"/>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="F_PRED" symbolType="real">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="F_IND"/>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="tl_PRED" symbolType="real">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="tl_IND"/>
				</ct:Assign>
			</ct:Variable>
			<ct:Variable symbId="V_PRED" symbolType="real">
				<ct:Assign>
					<ct:SymbRef blkIdRef="pm" symbIdRef="V_IND"/>
				</ct:Assign>
			</ct:Variable>
		</StructuralModel>
		<ObservationModel blkId="om1">
			<ContinuousData>
				<Standard symbId="Y1">
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="ts_PRED"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="additiveError"/>
								<math:FunctionArgument symbId="additive">
									<ct:SymbRef blkIdRef="pm" symbIdRef="ADD_SMALL"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="EPS"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
		<ObservationModel blkId="om2">
			<ContinuousData>
				<Standard symbId="Y2">
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="F_PRED"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="additiveError"/>
								<math:FunctionArgument symbId="additive">
									<ct:SymbRef blkIdRef="pm" symbIdRef="ADD_SMALL"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="EPS"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
		<ObservationModel blkId="om3">
			<ContinuousData>
				<Standard symbId="Y3">
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="tl_PRED"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="additiveError"/>
								<math:FunctionArgument symbId="additive">
									<ct:SymbRef blkIdRef="pm" symbIdRef="ADD_SMALL"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="EPS"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
		<ObservationModel blkId="om4">
			<ContinuousData>
				<Standard symbId="Y4">
					<Output>
						<ct:SymbRef blkIdRef="sm" symbIdRef="V_PRED"/>
					</Output>
					<ErrorModel>
						<ct:Assign>
							<math:FunctionCall>
								<ct:SymbRef symbIdRef="additiveError"/>
								<math:FunctionArgument symbId="additive">
									<ct:SymbRef blkIdRef="pm" symbIdRef="ADD_SMALL"/>
								</math:FunctionArgument>
							</math:FunctionCall>
						</ct:Assign>
					</ErrorModel>
					<ResidualError>
						<ct:SymbRef blkIdRef="pm" symbIdRef="EPS"/>
					</ResidualError>
				</Standard>
			</ContinuousData>
		</ObservationModel>
	</ModelDefinition>
	<TrialDesign xmlns="http://www.pharmml.org/pharmml/0.8/TrialDesign">
		<ExternalDataSet toolName="NONMEM" oid="nm_ds">
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="ID"/>
				<ct:SymbRef blkIdRef="vm_mdl" symbIdRef="ID"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="TIME"/>
				<ct:SymbRef symbIdRef="T"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="WEIGHT"/>
				<ct:SymbRef blkIdRef="cm" symbIdRef="WEIGHT"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="HEIGHT"/>
				<ct:SymbRef blkIdRef="cm" symbIdRef="HEIGHT"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="HSTATUS"/>
				<ct:SymbRef blkIdRef="cm" symbIdRef="HSTATUS"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="AGE"/>
				<ct:SymbRef blkIdRef="cm" symbIdRef="AGE"/>
			</ColumnMapping>
			<ColumnMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="FEMALE"/>
				<ct:SymbRef blkIdRef="cm" symbIdRef="FEMALE"/>
			</ColumnMapping>
			<MultipleDVMapping>
				<ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="DV"/>
				<Piecewise>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om1" symbIdRef="Y1"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="DVID"/>
								<ct:Int>1</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om2" symbIdRef="Y2"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="DVID"/>
								<ct:Int>2</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om3" symbIdRef="Y3"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="DVID"/>
								<ct:Int>3</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
					<math:Piece>
					   	<ct:SymbRef blkIdRef="om4" symbIdRef="Y4"/>
						<math:Condition>
							<math:LogicBinop op="eq">
							<ds:ColumnRef xmlns="http://www.pharmml.org/pharmml/0.8/Dataset" columnIdRef="DVID"/>
								<ct:Int>4</ct:Int>
					   		</math:LogicBinop>
					   	</math:Condition>
					</math:Piece>
				</Piecewise>
			</MultipleDVMapping>
			<DataSet xmlns="http://www.pharmml.org/pharmml/0.8/Dataset">
				<Definition>
					<Column columnId="ID" columnType="id" valueType="int" columnNum="1"/>
					<Column columnId="TIME" columnType="idv" valueType="real" columnNum="2"/>
					<Column columnId="WEIGHT" columnType="covariate" valueType="real" columnNum="3"/>
					<Column columnId="HEIGHT" columnType="covariate" valueType="real" columnNum="4"/>
					<Column columnId="HSTATUS" columnType="covariate" valueType="real" columnNum="5"/>
					<Column columnId="AGE" columnType="covariate" valueType="real" columnNum="6"/>
					<Column columnId="FEMALE" columnType="covariate" valueType="real" columnNum="7"/>
					<Column columnId="DV" columnType="dv" valueType="real" columnNum="8"/>
					<Column columnId="DVID" columnType="dvid" valueType="int" columnNum="9"/>
				</Definition>
				<ExternalFile oid="id">
					<path>Simulated_magni2000_subjects.csv</path>
					<format>CSV</format>
					<delimiter>COMMA</delimiter>
				</ExternalFile>
			</DataSet>
		</ExternalDataSet>
	</TrialDesign>
	<ModellingSteps xmlns="http://www.pharmml.org/pharmml/0.8/ModellingSteps">
		<EstimationStep oid="estimStep_1">
			<ExternalDataSetReference>
				<ct:OidRef oidRef="nm_ds"/>
			</ExternalDataSetReference>
			<ParametersToEstimate>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="mtsn"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="mtso"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="mtsd"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="mFn"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="mFo"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="mFd"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="atl"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="btl"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="aVm"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="bVm"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="aVf"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="bVf"/>
				</ParameterEstimation>
				<ParameterEstimation>
					<ct:SymbRef blkIdRef="pm" symbIdRef="invOMEGA_PAR"/>
				</ParameterEstimation>
			</ParametersToEstimate>
			<Operation order="1" opType="generic">
				<Property name="algo">
					<ct:Assign>
						<ct:String>mcmc</ct:String>
					</ct:Assign>
				</Property>
			</Operation>
			<Operation order="2" opType="BUGS">
				<Property name="nchains">
					<ct:Assign>
						<ct:Int>1</ct:Int>
					</ct:Assign>
				</Property>
				<Property name="burnin">
					<ct:Assign>
						<ct:Int>1</ct:Int>
					</ct:Assign>
				</Property>
				<Property name="niter">
					<ct:Assign>
						<ct:Int>1</ct:Int>
					</ct:Assign>
				</Property>
				<Property name="winbugsgui">
					<ct:Assign>
						<ct:String>true</ct:String>
					</ct:Assign>
				</Property>
			</Operation>
		</EstimationStep>
		<mstep:StepDependencies>
			<mstep:Step>
				<ct:OidRef oidRef="estimStep_1"/>
			</mstep:Step>
		</mstep:StepDependencies>
	</ModellingSteps>		
</PharmML>
